PROTECTIVE EFFECT OF MISOPROSTOL, A SYNTHETIC PROSTAGLANDIN-E1 ANALOG, ON CERULEIN-INDUCED ACUTE-PANCREATITIS IN RATS

被引：15

作者：

BUSCAIL, L

BUSSENOT, I

BOUISSON, M

SENEGASBALAS, F

BERTRAND, C

BALAS, D

VAYSSE, N

RIBET, A

机构：

[1] INSERM U151, CHU Rangueil, Toulouse

来源：

PANCREAS | 1990年 / 5卷 / 02期

关键词：

Acute pancreatitis; Cerulein; Lysosomes; Misoprostol; Rat; Stereology;

D O I：

10.1097/00006676-199003000-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 μg/kg/h subcutane-ously), cerulein and misoprostol (500 μg/kg intraperitoneally at 0 and 4 h), or saline. Rats were killed 6 h after the first injection. Misoprostol treatment significantly reduced interstitial edema and acinar cell lesions induced by hy-perstimulation. Pancreatic amylase and chymotrypsin contents were increased by cerulein and returned towards control levels in the misoprostol-treated group. The lysosomal volume density and the pancreatic β-D-glucuronidase activity were significantly increased after hyperstimulation. The two parameters were significantly reduced by misoprostol. A protective effect of misoprostol against lesions induced by cerulein hyperstimulation would be a consequence of a lysosomal stabilizating effect. © 1990 Raven Press, Ltd., New York.

引用

页码：171 / 176

页数：6

共 43 条

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