DIAMINE OXIDASE ACTIVITY IN A MODEL OF MULTISTEP HEPATOCARCINOGENESIS

被引：9

作者：

SESSA, A ^{[1
]}

DESIDERIO, MA ^{[1
]}

PERIN, A ^{[1
]}

机构：

[1] UNIV MILAN,IST PATOL GEN,I-20133 MILAN,ITALY

来源：

CANCER LETTERS | 1990年 / 51卷 / 01期

关键词：

diamine oxidase; hepatocarcinogenesis; hepatomas;

D O I：

10.1016/0304-3835(90)90233-N

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of rats with a complete hepatocarcinogenic regimen (diethylnitrosamine, 2-acetylaminofluorene and partial hepatectomy) produced a prolonged stimulation of diamine oxidase activity in liver, which showed early and persistent preneoplastic nodules. Diethylnitrosamine or partial hepatectomy tested separately caused a transient increase in enzyme activity. Early nodules, which were positive for γ-glutamyltransferase activity, and hepatomas showed diamine oxidase activity of approximately 5- and 13-fold that of control liver, respectively. These results indicate an activation of terminal catabolism of polyamines in preneoplastic nodules and in hepatomas. © 1990.

引用

页码：75 / 78

页数：4

共 22 条

[1]

BAYLIN SB, 1985, STRUCTURE FUNCTIONS, P187

[2]

CAMERON R, 1978, CANCER RES, V38, P823

[3]

ENOMOTO K, 1982, CANCER RES, V42, P2330

[4] CHEMICAL CARCINOGENESIS - THE LIVER AS A MODEL [J].