ASSIGNMENT OF THE HUMAN GENE FOR THE ALPHA-1 SUBUNIT OF THE CARDIAC DHP-SENSITIVE CA2+ CHANNEL (CCHL1A1) TO CHROMOSOME-12P12-PTER

被引:23
作者
POWERS, PA
GREGG, RG
LALLEY, PA
LIAO, M
HOGAN, K
机构
[1] UNIV WISCONSIN,DEPT PEDIAT,MADISON,WI 53705
[2] UNIV WISCONSIN,WAISMAN CTR MENTAL RETARDAT & DEV,MADISON,WI 53705
[3] WAYNE STATE UNIV,CTR MOLEC BIOL,DETROIT,MI 48202
[4] UNIV COLORADO,HLTH SCI CTR,ELEANOR ROOSEVELT INST CANC RES,DEPT PEDIAT,DENVER,CO 80262
关键词
D O I
10.1016/0888-7543(91)90471-P
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A human clone corresponding to the gene encoding the α1 subunit of the cardiac dihydropyridine-sensitive calcium channel (CCHL1A1) has been isolated and partially sequenced. Oligonucleotides based on the human sequence were constructed and used in the polymerase chain reaction to amplify specifically this human gene in human-rodent somatic cell hybrids. Using somatic cell hybrids that contained defined regions of human chromosome 12, the human α1 subunit of the cardiac dihydropyridine-sensitive calcium channel has been assigned to the short arm of chromosome 12 in the interval 12p12-pter. © 1991.
引用
收藏
页码:835 / 839
页数:5
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