MASSIVE DIPHENHYDRAMINE POISONING RESULTING IN A WIDE-COMPLEX TACHYCARDIA - SUCCESSFUL TREATMENT WITH SODIUM-BICARBONATE

被引:41
作者
CLARK, RF
VANCE, MV
机构
[1] Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, AZ
关键词
DIPHENHYDRAMINE; OVERDOSE; SODIUM BICARBONATE; DIPHENHYDRAMINE OVERDOSE;
D O I
10.1016/S0196-0644(05)80897-2
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Diphenhydramine poisoning is characterized most often by anticholinergic effects. Cardiotoxicity and circulatory collapse have rarely been reported after massive ingestions of diphenhydramine and other H-1-receptor-blocking agents, although these substances have local anesthetic properties and have been studied as antiarrhythmics. We report the case of a patient who developed a wide-complex tachycardia as a complication of acute diphenhydramine poisoning that responded to IV sodium bicarbonate.
引用
收藏
页码:318 / 321
页数:4
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共 20 条
[1]  
Litovitz, Schmitz, Bailey, 1989 Annual report of the American Association of Poison Control Centers National Data Collection System, Am J Emerg Med, 8, pp. 394-442, (1990)
[2]  
Garrison, Histamine, bradykinin, 5-hydroxytryptamine, and their antagonists, The Pharmacological Basis of Therapeutics, pp. 575-599, (1990)
[3]  
Ellenhorne, Barceloux, Medical Toxicology, pp. 537-541, (1988)
[4]  
Krenzelok, Anderson, Mirick, Massive diphenhydramine overdose resulting in death, Ann Emerg Med, 11, pp. 212-213, (1982)
[5]  
Wyngaarden, Seevers, The toxic effects of antihistaminic drugs, JAMA, 145, pp. 277-282, (1951)
[6]  
Huxtable, Landwirth, Diphenhydramine poisoning treated by exchange transfusion, Am J Dis Child, 106, pp. 496-500, (1963)
[7]  
Hestand, Teske, Diphenhydramine hydrochloride intoxication, J Pediatr, 90, pp. 1017-1018, (1977)
[8]  
Freedburg, Friedman, Palu, Et al., Cardiogenic shock due to antihistamine overdose, JAMA, 257, pp. 660-661, (1987)
[9]  
Monahan, Ferguson, Killeavy, Et al., Torsades de pointes occurring in association with terfenidine use, JAMA, 264, pp. 2788-2790, (1990)
[10]  
Craft, Torsade de pointes after astemizole overdose, Br Med J, 292, (1986)