DEPURINATION OF (DIEN)PT(II) COMPLEXES OF PURINE DEOXYRIBONUCLEOSIDES - COMPARISON WITH THE EFFECTS OF (DIEN)PD(II) ION COMPLEXING

被引：8

作者：

ARPALAHTI, J ^{[1
]}

JOKILAMMI, A ^{[1
]}

HAKALA, H ^{[1
]}

LONNBERG, H ^{[1
]}

机构：

[1] UNIV TURKU,DEPT CHEM,SF-20500 TURKU 50,FINLAND

来源：

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY | 1991年 / 4卷 / 05期

关键词：

D O I：

10.1002/poc.610040507

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

First-order rate constants for the hydrolytic depurination of 2'-deoxyinosine and its various (dien)Pt(II) ion complexes were measured over the acidic pH range. The rate profiles obtained indicate that the uncomplexed nucleoside and its N1-(dien)Pt(II) complex are depurinated via mono- and di-protonated species, whereas the N7-(dien)Pt(II) and N1,N7-di(dien)Pt(II) complexes exhibit significant spontaneous hydrolysis, which competes with a markedly retarded acid-catalysed reaction. Rate constants for the various partial reactions were calculated and the results were employed to explain the effects that (dien)Pd(II) ion exerted on depurination rates of the same compounds. Similar measurements were carried out with the N1,N7-di(dien)Pt(II) complex of 2'-deoxyadenosine in order to further the understanding of the previously reported rate-enhancing effect of (dien)Pd(II) ion on the depurination of 2'-deoxyadenosine.

引用

页码：301 / 309

页数：9

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