MR IMAGING OF SMALL HEPATOCELLULAR-CARCINOMA - EFFECT OF INTRATUMORAL COPPER CONTENT ON SIGNAL INTENSITY

被引：77

作者：

EBARA, M ^{[1
]}

WATANABE, S ^{[1
]}

KITA, K ^{[1
]}

YOSHIKAWA, M ^{[1
]}

SUGIURA, N ^{[1
]}

OHTO, M ^{[1
]}

KONDO, F ^{[1
]}

KONDO, Y ^{[1
]}

机构：

[1] CHIBA UNIV HOSP,DEPT PATHOL 2,CHIBA 280,JAPAN

来源：

RADIOLOGY | 1991年 / 180卷 / 03期

关键词：

COPPER; LIVER; MR STUDIES; LIVER NEOPLASMS; NEOPLASMS;

D O I：

10.1148/radiology.180.3.1651523

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Small (< 5 cm) hepatocellular carcinomas (HCCs) in 45 of 112 patients (40.2%) had a high-signal-intensity pattern (relative to that of liver) on T1-weighted magnetic resonance (MR) images. To identify the cause of this pattern, specimens of histologically defined HCC with high- (n = 21), iso- (n = 6), and low- (n = 22) intensity patterns were histologically evaluated for paramagnetic ionic forms of metals. The incidence of steatosis, clear cell formation, and copper accumulation was statistically (P < .01) higher in tumors with the high-intensity pattern than in those with other patterns. Of 17 HCCs that stained positive for copper, 16 (94%) had a high-intensity pattern; the pattern of one tumor (6%) was isointense. All 21 tumors with the high-intensity pattern had at least one of the findings of steatosis, clear cell formation, or copper accumulation. These features were evident in only four of 28 tumors (14%) with an isoor low-intensity pattern. Thus, copper accumulation might be a cause of the high-intensity pattern on T1-weighted images of small HCCs.

引用

页码：617 / 621

页数：5

共 34 条

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