INVITRO NEUTRALIZATION OF CHLAMYDIA-TRACHOMATIS BY MONOVALENT FAB ANTIBODY SPECIFIC TO THE MAJOR OUTER-MEMBRANE PROTEIN

被引：47

作者：

SU, H ^{[1
]}

CALDWELL, HD ^{[1
]}

机构：

[1] NIAID,ROCKY MT LABS,INTRACELLULAR PARASITES LAB,HAMILTON,MT 59840

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 08期

关键词：

D O I：

10.1128/IAI.59.8.2843-2845.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monovalent Fab antibodies to serovar- and subspecies-specific epitopes of the major outer membrane protein (MOMP) of Chlamydia trachomatis neutralized infectivity for hamster kidney cells by preventing chlamydial attachment. These findings exclude the aggregation of chlamydiae as a mechanism of anti-MOMP neutralization and provide additional evidence in support of the MOMP as a chlamydial adhesin.

引用

页码：2843 / 2845

页数：3

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