TREATMENT OF DRUG-INDUCED AGRANULOCYTOSIS WITH RECOMBINANT GRANULOCYTE-COLONY-STIMULATING FACTOR (RH G-CSF)

被引：21

作者：

WILLFORT, A

LORBER, C

KAPIOTIS, S

SERTL, S

HAINZ, R

KIRCHWEGER, P

JAGER, U

KYRLE, PA

LECHNER, K

GEISSLER, K

机构：

[1] UNIV VIENNA,DEPT INTERNAL MED 1,DIV HEMATOL & BLOOD COAGULAT,WAHRINGER GURTEL 18-20,A-1090 VIENNA,AUSTRIA

[2] CLIN INST LAB DIAG,VIENNA,AUSTRIA

[3] KRANKENHAUS RUDOLFSTIFTUNG,VIENNA,AUSTRIA

[4] KRANKENHAUS HORN,VIENNA,AUSTRIA

[5] UNIV VIENNA,DEPT INTERNAL MED 4,DIV PULMONOL,A-1010 VIENNA,AUSTRIA

来源：

ANNALS OF HEMATOLOGY | 1993年 / 66卷 / 05期

关键词：

DRUG-INDUCED AGRANULOCYTOSIS; G-CSF;

D O I：

10.1007/BF01738472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Five patients with drug-induced agranulocytosis received 300 mug recombinant human granulocyte colony-stimulating factor (rh G-CSF) subcutaneously twice daily for 2-5 days. G-CSF therapy resulted in a steep increase of the neutrophil count, which was faster than that in patients with spontaneous recovery reported in the literature. In all four patients with infectious complications fever rapidly declined with the increase of granulocytes. G-CSF may be useful in the management of drug-induced agranulocytosis.

引用

页码：241 / 244

页数：4

共 15 条

[1] ACUTE DRUG-INDUCED AGRANULOCYTOSIS - COMPARISON BETWEEN OPENWARD TREATMENT AND ANTI-MICROBIAL DECONTAMINATION IN A PLASTIC ISOLATION BED SYSTEM (RETROSPECTIVE STUDY OF 30 CASES) [J].