Interaction of T Lymphocytes with Cerebral Endothelial Cells in vitro

被引：43

作者：

Wekerle, Hartmut ^{[1
]}

Engelhardt, Britta ^{[1
]}

Risau, Werner ^{[1
]}

Meyermann, Richard ^{[2
]}

机构：

[1] Max Planck Inst Psychiat, D-8033 Martinsried, Germany

[2] Univ Tubingen, Inst Brain Res, D-7400 Tubingen, Germany

来源：

BRAIN PATHOLOGY | 1991年 / 1卷 / 02期

关键词：

D O I：

10.1111/j.1750-3639.1991.tb00647.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

As a prerequisite of inflammatory lesion formation in (auto-)immune disease of the central nervous system, lymphocytes have to interact with brain endothelia. In recent years much progress has been made towards a better understanding of mechanisms and factors involved in organ specific homing of lymphocytes. Many lines of evidence indicate that T lymphocytes recognizing antigens which are exclusively beyond the blood-brain barrier cross this barrier only when they are in an activated state, irrespective of their antigen specificity. Antigen presentation by blood-brain barrier endothelia, however, may play a role in later stages of florid inflammation.

引用

页码：107 / 114

页数：8

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