STIMULATION OF DOPAMINE BIOSYNTHESIS IN CULTURED PC-12 PHEOCHROMOCYTOMA CELLS BY THE COENZYME NICOTINAMIDE ADENINEDINUCLEOTIDE (NADH)

被引：29

作者：

VRECKO, K

BIRKMAYER, JGD

KRAINZ, J

机构：

[1] GRAZ UNIV, INST MED CHEM, A-8010 GRAZ, AUSTRIA

[2] INST PARKINSON THERAPY, VIENNA, AUSTRIA

来源：

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION | 1993年 / 5卷 / 02期

关键词：

PARKINSONS DISEASE; TYROSINE HYDROXYLASE; NICOTINAMIDE ADENINE DINUCLEOTIDE (NADH); DOPAMINE; PC-12; CELLS;

D O I：

10.1007/BF02251205

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The activity of the tyrosine hydroxylase. the enzyme which is diminished in the brains of Parkinson patients, has been measured in cultured PC 12 rat phaeochromocytoma cells. In the same way dopamine content in the medium after incubating these cells with or without NADH was assayed. The experiment shows that NADH is able to increase the activity of the tyrosine hydroxylase and dopamine - production in PC 12 cells up to 6 times. The results provide evidence that NADH is able to stimulate dopamine - biosynthesis directly.

引用

页码：147 / 156

页数：10

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