EXOGENOUS NT-3 MITIGATES THE TRANSGANGLIONIC NEUROPEPTIDE-Y RESPONSE TO SCIATIC-NERVE INJURY

被引：44

作者：

OHARA, S

TANTUWAYA, V

DISTEFANO, PS

SCHMIDT, RE

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT PATHOL NEUROPATHOL, ST LOUIS, MO 63110 USA

[2] WASHINGTON UNIV, SCH MED, DEPT NEUROL, ST LOUIS, MO USA

[3] WASHINGTON UNIV, SCH MED, DEPT NEUROSURG, ST LOUIS, MO USA

[4] REGENERON PHARMACEUT INC, TARRYTOWN, NY 10591 USA

来源：

BRAIN RESEARCH | 1995年 / 699卷 / 01期

关键词：

NEUROPATHY; NEUROPEPTIDE; NEUROTROPHIN; GROWTH FACTOR;

D O I：

10.1016/0006-8993(95)01021-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral sciatic nerve transection injury produces a marked increase in immunoreactive NPY in rat lumbar DRG and, as a 'transganglionic' response, in their central axonal projections to the dorsal spinal cord and gracile nuclei. Local application of neurotrophin-3 (NT-3) using implanted silicone chambers applied to the proximal transected sciatic nerve stump significantly diminished the transganglionic NPY response in the gracile nucleus and spinal cord but did not affect the CGRP transganglionic response. Conversely, local application of NGF affected the transganglionic CGRP response to axotomy but did not substantially affect transganglionic gracile NPY upregulation.

引用

收藏

页码：143 / 148

页数：6

相关论文

共 31 条

[1] SUBSTANCE-P IN SPINAL-CORD DORSAL HORN DECREASES FOLLOWING PERIPHERAL-NERVE INJURY [J].

BARBUT, D ;

POLAK, JM ;

WALL, PD .

BRAIN RESEARCH, 1981, 205 (02) :289-298

[2] GAP-43 MESSENGER-RNA IN RAT SPINAL-CORD AND DORSAL-ROOT GANGLIA NEURONS - DEVELOPMENTAL-CHANGES AND REEXPRESSION FOLLOWING PERIPHERAL-NERVE INJURY [J].

CHONG, MS ;

FITZGERALD, M ;

WINTER, J ;

HUTSAI, M ;

EMSON, PC ;

WIESE, U ;

WOOLF, CJ .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (10) :883-895

[3] THE NEUROTROPHINS BDNF, NT-3, AND NGF DISPLAY DISTINCT PATTERNS OF RETROGRADE AXONAL-TRANSPORT IN PERIPHERAL AND CENTRAL NEURONS [J].

DISTEFANO, PS ;

FRIEDMAN, B ;

RADZIEJEWSKI, C ;

ALEXANDER, C ;

BOLAND, P ;

SCHICK, CM ;

LINDSAY, RM ;

WIEGAND, SJ .

NEURON, 1992, 8 (05) :983-993

[4] MICROINJECTION OF NEUROPEPTIDE-Y INTO THE SUPERFICIAL DORSAL HORN REDUCES STIMULUS-EVOKED RELEASE OF IMMUNOREACTIVE SUBSTANCE-P IN THE ANESTHETIZED CAT [J].

DUGGAN, AW ;

HOPE, PJ ;

LANG, CW .

NEUROSCIENCE, 1991, 44 (03) :733-740

[5] DIFFERENTIAL EXPRESSION OF MESSENGER-RNAS FOR NEUROTROPHINS AND THEIR RECEPTORS AFTER AXOTOMY OF THE SCIATIC-NERVE [J].

FUNAKOSHI, H ;

FRISEN, J ;

BARBANY, G ;

TIMMUSK, T ;

ZACHRISSON, O ;

VERGE, VMK ;

PERSSON, H .

JOURNAL OF CELL BIOLOGY, 1993, 123 (02) :455-465

[6]

Gratto K. A., 1994, Society for Neuroscience Abstracts, V20, P1098

[7] DIFFERENTIAL REGULATION OF MESSENGER-RNA ENCODING NERVE GROWTH-FACTOR AND ITS RECEPTOR IN RAT SCIATIC-NERVE DURING DEVELOPMENT, DEGENERATION, AND REGENERATION - ROLE OF MACROPHAGES [J].

HEUMANN, R ;

LINDHOLM, D ;

BANDTLOW, C ;

MEYER, M ;

RADEKE, MJ ;

MISKO, TP ;

SHOOTER, E ;

THOENEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8735-8739

[8] MESSENGER PLASTICITY IN PRIMARY SENSORY NEURONS FOLLOWING AXOTOMY AND ITS FUNCTIONAL IMPLICATIONS [J].

HOKFELT, T ;

ZHANG, X ;

WIESENFELDHALLIN, Z .

TRENDS IN NEUROSCIENCES, 1994, 17 (01) :22-30

[9] SIMILARITIES AND DIFFERENCES IN THE WAY NEUROTROPHINS INTERACT WITH THE TRK RECEPTORS IN NEURONAL AND NONNEURONAL CELLS [J].

IP, NY ;

STITT, TN ;

TAPLEY, P ;

KLEIN, R ;

GLASS, DJ ;

FANDL, J ;

GREENE, LA ;

BARBACID, M ;

YANCOPOULOS, GD .

NEURON, 1993, 10 (02) :137-149

[10]

JELLINGER K, 1973, PROGR NEUROPATHOLOGY, V2, P129

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