MAGNETIC-RESONANCE-IMAGING IN THE EVALUATION OF CLINICAL-TRIALS IN MULTIPLE-SCLEROSIS

被引:69
作者
PATY, DW
LI, DKB
OGER, JJF
KASTRUKOFF, L
KOOPMANS, R
TANTON, E
ZHAO, GJ
机构
[1] UNIV BRITISH COLUMBIA,DEPT MED,DIV NEUROL,VANCOUVER V6T 1W5,BC,CANADA
[2] UNIV BRITISH COLUMBIA,DEPT RADIOL,MRI UNIT,VANCOUVER,BC,CANADA
关键词
D O I
10.1002/ana.410360721
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Magnetic resonance imaging (MRI) provides an objective method of evaluating multiple sclerosis clinical trials and is at least five times more sensitive to disease activity. In a recent clinical trial, MRI was also approximately twice as sensitive as clinical measurements to the treatment effect of a drug.
引用
收藏
页码:S95 / S96
页数:2
相关论文
共 13 条
[1]  
[Anonymous], 1990, ANN NEUROL, V27, P591
[2]   QUANTITATIVE BRAIN MRI LESION LOAD PREDICTS THE COURSE OF CLINICALLY ISOLATED SYNDROMES SUGGESTIVE OF MULTIPLE-SCLEROSIS [J].
FILIPPI, M ;
HORSFIELD, MA ;
MORRISSEY, SP ;
MACMANUS, DG ;
RUDGE, P ;
MCDONALD, WI ;
MILLER, DH .
NEUROLOGY, 1994, 44 (04) :635-641
[3]   SYSTEMIC LYMPHOBLASTOID INTERFERON THERAPY IN CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS .1. CLINICAL AND MRI EVALUATION [J].
KASTRUKOFF, LF ;
OGER, JJ ;
HASHIMOTO, SA ;
SACKS, SL ;
LI, DK ;
PALMER, MR ;
KOOPMANS, RA ;
PETKAU, AJ ;
BERKOWITZ, J ;
PATY, DW .
NEUROLOGY, 1990, 40 (03) :479-486
[4]  
KOOPMANS R A, 1992, Neurology, V42, P210
[5]  
Koopmans R A, 1993, J Neuroimaging, V3, P163
[6]   THE LESION OF MULTIPLE-SCLEROSIS - IMAGING OF ACUTE AND CHRONIC STAGES [J].
KOOPMANS, RA ;
LI, DKB ;
OGER, JJF ;
MAYO, J ;
PATY, DW .
NEUROLOGY, 1989, 39 (07) :959-963
[7]   THE PATHOLOGICAL EVOLUTION OF MULTIPLE-SCLEROSIS [J].
MCDONALD, WI ;
MILLER, DH ;
BARNES, D .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1992, 18 (04) :319-334
[8]   THE SIGNIFICANCE OF BRAIN MAGNETIC-RESONANCE-IMAGING ABNORMALITIES AT PRESENTATION WITH CLINICALLY ISOLATED SYNDROMES SUGGESTIVE OF MULTIPLE-SCLEROSIS - A 5-YEAR FOLLOW-UP-STUDY [J].
MORRISSEY, SP ;
MILLER, DH ;
KENDALL, BE ;
KINGSLEY, DPE ;
KELLY, MA ;
FRANCIS, DA ;
MACMANUS, DG ;
MCDONALD, WI .
BRAIN, 1993, 116 :135-146
[9]   MRI IN THE DIAGNOSIS OF MS - A PROSPECTIVE-STUDY WITH COMPARISON OF CLINICAL-EVALUATION, EVOKED-POTENTIALS, OLIGOCLONAL BANDING, AND CT [J].
PATY, DW ;
OGER, JJF ;
KASTRUKOFF, LF ;
HASHIMOTO, SA ;
HOOGE, JP ;
EISEN, AA ;
EISEN, KA ;
PURVES, SJ ;
LOW, MD ;
BRANDEJS, V ;
ROBERTSON, WD ;
LI, DKB .
NEUROLOGY, 1988, 38 (02) :180-185
[10]   INTERFERON BETA-1B IS EFFECTIVE IN RELAPSING-REMITTING MULTIPLE-SCLEROSIS .2. MRI ANALYSIS RESULTS OF A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].
PATY, DW ;
LI, DKB ;
DUQUETTE, P ;
GIRARD, M ;
DESPAULT, L ;
DUBOIS, R ;
KNOBLER, RL ;
LUBLIN, FD ;
KELLEY, L ;
FRANCIS, GS ;
LAPIERRE, Y ;
ANTEL, J ;
FREEDMAN, M ;
HUM, S ;
GREENSTEIN, JI ;
MISHRA, B ;
MULDOON, J ;
WHITAKER, JN ;
EVANS, BK ;
LAYTON, B ;
SIBLEY, WA ;
LAGUNA, J ;
KRIKAWA, J ;
PATY, DW ;
OGER, JJ ;
KASTRUKOFF, LF ;
MOORE, GRW ;
HASHIMOTO, SA ;
MORRISON, W ;
NELSON, J ;
GOODIN, DS ;
MASSA, SM ;
GUTTERIDGE, E ;
ARNASON, BGW ;
NORONHA, A ;
REDER, AT ;
MARTIA, R ;
EBERS, GC ;
RICE, GPA ;
LESAUX, J ;
JOHNSON, KP ;
PANITCH, HS ;
BEVER, CT ;
CONWAY, K ;
WALLENBERG, JC ;
BEDELL, L ;
VANDENNOORT, S ;
WEINSHENKER, B ;
WEISS, W ;
REINGOLD, S .
NEUROLOGY, 1993, 43 (04) :662-667