REVERSED BCR/ABL REARRANGEMENT DETECTED BY FISH IN PHILADELPHIA NEGATIVE CHRONIC MYELOCYTIC-LEUKEMIA

被引：17

作者：

ABELIOVICH, D

YEHUDA, O

KRICHEVSKY, S

NAGLER, A

BENNERIAH, S

WERNER, M

LUDKOVSKY, O

BENYEHUDA, D

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH UNIV HOSP,HADASSAH MED SCH,DEPT HEMATOL,IL-91120 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,HADASSAH UNIV HOSP,HADASSAH MED SCH,DEPT HUMAN GENET,IL-91120 JERUSALEM,ISRAEL

[3] HEBREW UNIV JERUSALEM,HADASSAH UNIV HOSP,HADASSAH MED SCH,DEPT BONE MARROW TRANSPLANT,IL-91120 JERUSALEM,ISRAEL

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 81卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)00321-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated leukemic cells from a patient with chronic myelocytic leukemia (CML) and a normal 46,XX karyotype. Molecular studies revealed rearrangement of the M-bcr region and formation of BCR/ABL fusion mRNA with b3a2 configuration. Fluorescence in situ hybridization (FISH) using the abl probe showed signal on both chromosomes 9 band q34, while the bcr probe hybridized to one chromosome 22 and to one chromosome 9. In this case, as in three other cases recently described (Hagemeijer et al. and Nachava et al.), the bcr/abl rearrangement is shown to be on 9q34, instead of the usual location on 22q11.

引用

页码：115 / 117

页数：3

共 22 条

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