INOSITOL HEXAKISPHOSPHATE STIMULATES CA-45(2+) UPTAKE IN ANTERIOR-PITUITARY-CELLS IN CULTURE

被引：13

作者：

SORTINO, MA ^{[1
]}

NICOLETTI, F ^{[1
]}

CANONICO, PL ^{[1
]}

机构：

[1] UNIV CATANIA,SCH MED,INST PHARMACOL,I-95125 CATANIA,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1990年 / 189卷 / 01期

关键词：

INSP6; PITUITARY; CA2+;

D O I：

10.1016/0922-4106(90)90238-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inositol hexakisphosphate (InsP6) is thought to act as an intercellular signal molecule in the central nervous system. We report that InsP6 stimulates Ca-45(2+) uptake in cultured anterior pituitary cells. This effect is concentration-dependent, is mimicked by inositolpentakis phosphate (InsP5) but not by inositoltetrakis phosphate (InsP4), is present after 2 min of incubation, is independent of extracellular Na+ and insensitive to nifedipine and verapamil. These results suggest that InsP6, a putative metabolite of the inositol cycle, may regulate transmembrane mechanism in the pituitary.

引用

页码：115 / 118

页数：4

共 9 条

[1]

BALLA T, 1988, J BIOL CHEM, V263, P4083

[2]

BERRIDGE MJ, 1987, ANNU REV BIOCHEM, V56, P159, DOI 10.1146/annurev.bi.56.070187.001111

[3] NEURAL FUNCTION - METABOLISM AND ACTIONS OF INOSITOL METABOLITES IN MAMMALIAN BRAIN [J].