STEROL PATHWAY IN YEAST - IDENTIFICATION AND PROPERTIES OF MUTANT STRAINS DEFECTIVE IN MEVALONATE DIPHOSPHATE DECARBOXYLASE AND FARNESYL DIPHOSPHATE SYNTHETASE

被引：48

作者：

CHAMBON, C

LADEVEZE, V

SERVOUSE, M

BLANCHARD, L

JAVELOT, C

VLADESCU, B

KARST, F

机构：

[1] UNIV POITIERS,BIOCHIM & GENET MICROORGANISMES LAB,40 AVE RECLEUR PINEAU,F-86022 POITIERS,FRANCE

[2] CTR RECH PERNOD RICARD,MICROBIOL LAB,F-94015 CRETEIL,FRANCE

来源：

LIPIDS | 1991年 / 26卷 / 08期

关键词：

D O I：

10.1007/BF02536428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yeast mutant strains auxotrophic for ergosterol and blocked in mevalonate diphosphate decarboxylase (erg19) and farnesyl diphosphate (FPP) synthetase (erg20) were isolated. The main feature of the mutants blocked in FPP synthetase is their ability to excrete prenyl alcohols, such as geraniol and farnesol. The isolation of the functional ERG20 gene allowed us to show that farnesyl diphosphate synthetase could be a rate limiting enzyme in ergosterol biosynthesis in yeast.

引用

页码：633 / 636

页数：4

共 12 条

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