THE CHICK RETINAL MELATONIN RECEPTOR REVISITED - LOCALIZATION AND MODULATION OF AGONIST BINDING WITH GUANINE-NUCLEOTIDES

被引：51

作者：

LAITINEN, JT

SAAVEDRA, JM

机构：

[1] Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda

来源：

BRAIN RESEARCH | 1990年 / 528卷 / 02期

关键词：

Agonist binding; G-Protein; Melatonin; Receptor; Retina;

D O I：

10.1016/0006-8993(90)91681-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The chick retinal melatonin receptor was localized to the inner plexiform layer using 2-125I-melatonin and in vitro autoradiographic techniques. This receptor was of high affinity (Kd19.8 pM) and specificity and showed guanine nucleotide modulation of agonist binding . It thus behaves similarly to other recently characterized high affinity melatonin receptors. © 1990.

引用

页码：349 / 352

页数：4

共 26 条

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