THE ACUTE TOXICITY AND SUBLETHAL EFFECTS OF CHLOROTHALONIL IN CHANNEL CATFISH (ICTALURUS-PUNCTATUS)

被引：12

作者：

GALLAGHER, EP ^{[1
]}

CATTLEY, RC ^{[1
]}

DIGIULIO, RT ^{[1
]}

机构：

[1] CHEM IND INST TOXICOL,RES TRIANGLE PK,NC 27709

来源：

CHEMOSPHERE | 1992年 / 24卷 / 01期

关键词：

D O I：

10.1016/0045-6535(92)90561-5

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The in vivo toxicity and sublethal biochemical effects of chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) were evaluated in the channel catfish (lctalurus punctatus). The static 96hr LC50 value for chlorothalonil was 52-mu-g/L, indicating that chlorothalonil is highly acutely toxic to channel catfish. Sublethal chlorothalonil exposure for 6 days resulted in acute necrosis of the intestinal epithelial lining in 57% of the treated catfish. However, no treatment-related pathological lesions were observed in liver, gills, posterior kidney, brain, spleen, or heart. Catfish exposed to 13-mu-g/L chlorothalonil for 72 hr had increased tissue glutathione (GSH) concentrations in liver, posterior kidney and gills, suggesting a protective role of tissue GSH towards chlorothalonil exposure.

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页码：3 / 10

页数：8

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