IMMUNOLESIONING - SELECTIVE DESTRUCTION OF NEURONS USING IMMUNOTOXIN TO RAT NGF RECEPTOR

被引：336

作者：

WILEY, RG

OELTMANN, TN

LAPPI, DA

机构：

[1] VANDERBILT UNIV,DEPT NEUROL,NASHVILLE,TN 37240

[2] VANDERBILT UNIV,DEPT PHARMACOL,NASHVILLE,TN 37240

[3] WHITTIER INST,DEPT MOLEC & CELLULAR GROWTH BIOL,LA JOLLA,CA 92037

[4] VANDERBILT UNIV,MED DEPT ONCOL,NASHVILLE,TN 37240

来源：

BRAIN RESEARCH | 1991年 / 562卷 / 01期

关键词：

IMMUNOLESION; NGF RECEPTOR; IMMUNOTOXIN; 192; IGG; SYMPATHETIC NEURON;

D O I：

10.1016/0006-8993(91)91199-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

192 IgG, a monoclonal antibody to the rat nerve growth factor (NGF) receptor, was disulfide-coupled to saporin, a ribosome-inactivating protein. Systemic injection of 192 IgG-saporin destroyed sympathetic postganglionic neurons and some sensory neurons. Injection of 192 IgG-saporin into the lateral ventricle destroyed cholinergic neurons of the basal forebrain. These results show that antineuronal immunotoxins are a powerful approach that may prove useful in a variety of neurobiological applications.

引用

页码：149 / 153

页数：5

共 26 条

[1]

CHANDLER CE, 1984, J BIOL CHEM, V259, P6882

[2]

CRINO PB, 1990, J PHARMACOL EXP THER, V252, P651

[3] TEMPORAL PROGRESSION OF CORTICAL REORGANIZATION FOLLOWING NERVE INJURY [J].