CIRCADIAN-RHYTHM OF HISTAMINE-RELEASE FROM THE HYPOTHALAMUS OF FREELY MOVING RATS

被引：136

作者：

MOCHIZUKI, T ^{[1
]}

YAMATODANI, A ^{[1
]}

OKAKURA, K ^{[1
]}

HORII, A ^{[1
]}

INAGAKI, N ^{[1
]}

WADA, H ^{[1
]}

机构：

[1] OSAKA UNIV,FAC MED,DEPT OTOLARYNGOL,SUITA,OSAKA 565,JAPAN

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 02期

关键词：

HISTAMINE; NEUROTRANSMITTER RELEASE; MICRODIALYSIS; HYPOTHALAMUS; FREELY MOVING RAT; CIRCADIAN RHYTHM; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0031-9384(92)90157-W

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Using an in vivo microdialysis technique coupled with HPLC-fluorometry, the release of neuronal histamine from the anterior hypothalamic area was monitored continuously in conscious, freely moving rats under a 12:12 h light:dark cycle. Spontaneous locomotor activity of the rats was measured simultaneously using a locomotor activity counter. Histamine release gradually increased in the second half of the light period (1400-2000) and the average histamine release during the dark period (2000-0800, 0.20 +/- 0.02 pmol/30 min) was significantly higher than that during the light period (0.12 +/- 0.01 pmol/30 min). This clear circadian change in the release suggests that the central histaminergic system is related to the circadian rhythm of rats.

引用

页码：391 / 394

页数：4

共 23 条

[1]

CACABELOS R, 1990, METHOD FIND EXP CLIN, V12, P341

[2] INVIVO BRAIN DIALYSIS OF NEUROTRANSMITTERS [J].

DICHIARA, G .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (03) :116-121

[3]

INAGAKI N, 1990, EXP BRAIN RES, V80, P374

[4] ORGANIZATION OF HISTAMINERGIC FIBERS IN THE RAT-BRAIN [J].

INAGAKI, N ;

YAMATODANI, A ;

ANDOYAMAMOTO, M ;

TOHYAMA, M ;

WATANABE, T ;

WADA, H .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 273 (03) :283-300

[5] CHARACTERIZATION OF HISTAMINE-RELEASE FROM THE RAT HYPOTHALAMUS AS MEASURED BY INVIVO MICRODIALYSIS [J].

ITOH, Y ;

OISHI, R ;

NISHIBORI, M ;

SAEKI, K .

JOURNAL OF NEUROCHEMISTRY, 1991, 56 (03) :769-774

[6] EFFECT OF HISTAMINE DEPLETION ON CIRCADIAN VARIATIONS OF CORTICOTROPIN AND CORTICOSTERONE IN RATS [J].

ITOWI, N ;

YAMATODANI, A ;

CACABELOS, R ;

GOTO, M ;

WADA, H .

NEUROENDOCRINOLOGY, 1989, 50 (02) :187-192

[7] EFFECTS OF ALPHA-FLUOROMETHYLHISTIDINE ON SLEEP-WAKING PARAMETERS IN RATS [J].

KIYONO, S ;

SEO, ML ;

SHIBAGAKI, M ;

WATANABE, T ;

MAEYAMA, K ;

WADA, H .

PHYSIOLOGY & BEHAVIOR, 1985, 34 (04) :615-617

[8] SELECTIVE INHIBITORS OF BIOSYNTHESIS OF AMINERGIC NEUROTRANSMITTERS [J].

KOLLONITSCH, J ;

PATCHETT, AA ;

MARBURG, S ;

MAYCOCK, AL ;

PERKINS, LM ;

DOLDOURAS, GA ;

DUGGAN, DE ;

ASTER, SD .

NATURE, 1978, 274 (5674) :906-908

[9] INVOLVEMENT OF HISTAMINERGIC NEURONS IN AROUSAL MECHANISMS DEMONSTRATED WITH H-3 RECEPTOR LIGANDS IN THE CAT [J].

LIN, JS ;

SAKAI, K ;

VANNIMERCIER, G ;

ARRANG, JM ;

GARBARG, M ;

SCHWARTZ, JC ;

JOUVET, M .

BRAIN RESEARCH, 1990, 523 (02) :325-330

[10] EVIDENCE FOR HISTAMINERGIC AROUSAL MECHANISMS IN THE HYPOTHALAMUS OF CAT [J].

LIN, JS ;

SAKAI, K ;

JOUVET, M .

NEUROPHARMACOLOGY, 1988, 27 (02) :111-+

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