ONTOGENY OF DOPAMINE TRANSPORTER MESSENGER-RNA EXPRESSION IN THE RAT-BRAIN

被引：37

作者：

FUJITA, M

SHIMADA, S

NISHIMURA, T

UHL, GR

TOHYAMA, M

机构：

[1] OSAKA UNIV, SCH MED, BIOMED RES CTR, DIV TRACER KINET, SUITA, OSAKA 565, JAPAN

[2] JOHNS HOPKINS SCH MED, NATL INST DRUG ABUSE, ADDICT RES CTR, MOLEC NEUROBIOL LAB, BALTIMORE, MD 21224 USA

[3] JOHNS HOPKINS SCH MED, DEPT NEUROL, BALTIMORE, MD 21224 USA

[4] JOHNS HOPKINS SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21224 USA

来源：

MOLECULAR BRAIN RESEARCH | 1993年 / 19卷 / 03期

关键词：

DOPAMINE TRANSPORTER; IN-SITU HYBRIDIZATION HISTOCHEMISTRY; SUBSTANTIA-NIGRA; VENTRAL TEGMENTAL AREA; ONTOGENY;

D O I：

10.1016/0169-328X(93)90031-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ontogeny of dopamine transporter (DAT) gene expression was studied in the rat brain. DAT mRNA was first detected in neurons of the ventrocaudal mesencephalon on embryonic day 14 (E14). By E18, intensely ''pressing neurons in the ventral tegmental area and substantia nigra resembled the pattern found in adult midbrain. DAT mRNA is not abundant in the hypothalamus and the olfactory bulb at any stage of development. These results parallel those noted for tyrosine hydroxylase gene expression in mesencephalon.

引用

页码：222 / 226

页数：5

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