AUTONOMIC AND ARGININE VASOPRESSIN MODULATION OF THE HYPOXIA-INDUCED ATRIAL-NATRIURETIC-FACTOR RELEASE IN IMMATURE AND MATURE OVINE FETUSES

被引:16
作者
CHEUNG, CY
机构
[1] Division of Perinatal Medicine, Department of Reproductive Medicine, University of California, San Diego, California, La Jolla
关键词
FETAL DEVELOPMENT; REDUCED OXYGEN TENSION; AUTONOMIC NERVOUS SYSTEM; ATRIAL NATRIURETIC FACTOR; ARGININE VASOPRESSIN;
D O I
10.1016/S0002-9378(11)91731-1
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: This study investigated the maturational change in the atrial natriuretic factor response to hypoxia in ovine fetuses and the role of the autonomic nervous system and arginine vasopressin in modulating this response. STUDY DESIGN: Chronically catheterized ovine fetuses from 110 to 135 days' gestation were subjected to 30 minutes of hypoxia. The fetuses were either intact, treated with hexamethonium to block the autonomic nervous system, or treated with a pressor antagonist of arginine vasopressin. RESULTS: Hypoxia elevated plasma atrial natriuretic factor levels by 1635 +/- 265 pg/ml in immature fetuses; this response was greater than the increase of 748 +/- 189 pg/ml in mature fetuses (p < 0.0001). Blockade of the autonomic nervous system reduced the atrial natriuretic factor response and sup the vascular pressure changes to hypoxia in immature but not in mature fetuses. A vasopressin pressor antagonist suppressed the atrial natriuretic factor but not vascular pressure responses to hypoxia in mature fetuses. CONCLUSIONS: This study demonstrates that the immature fetus manifested a greater atrial natriuretic factor response to hypoxia than did the mature fetus. This enhanced response appeared to be dependent on the modulatory effects of the autonomic nervous system on vascular pressures during hypoxia. In addition, arginine vasopressin appeared to augment the atrial natriuretic factor response to hypoxia in the mature fetus independent of vascular pressure changes.
引用
收藏
页码:1443 / 1453
页数:11
相关论文
共 32 条
[1]   PLASMA RELEASE OF ATRIAL-NATRIURETIC-PEPTIDE IN RESPONSE TO BLOOD-VOLUME EXPANSION [J].
ANDERSON, JV ;
CHRISTOFIDES, ND ;
BLOOM, SR .
JOURNAL OF ENDOCRINOLOGY, 1986, 109 (01) :9-13
[2]   ACUTE HYPOXEMIA STIMULATES ATRIAL NATRIURETIC FACTOR SECRETION INVIVO [J].
BAERTSCHI, AJ ;
ADAMS, JM ;
SULLIVAN, MP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (02) :H295-H300
[3]   ALVEOLAR HYPOXIA IS A POWERFUL STIMULUS FOR ANF RELEASE IN CONSCIOUS LAMBS [J].
BAERTSCHI, AJ ;
TEAGUE, WG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04) :H990-H998
[4]   HYPOXIA-INDUCED RELEASE OF ATRIAL-NATRIURETIC-FACTOR (ANF) FROM THE ISOLATED RAT AND RABBIT HEART [J].
BAERTSCHI, AJ ;
HAUSMANINGER, C ;
WALSH, RS ;
MENTZER, RM ;
WYATT, DA ;
PENCE, RA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 140 (01) :427-433
[5]   NEURAL CONTROL OF ANF RELEASE IN HYPOXIA AND PULMONARY-HYPERTENSION [J].
BAERTSCHI, AJ ;
JIAO, JH ;
CARLSON, DE ;
CAMPBELL, RW ;
TEAGUE, WG ;
WILLSON, D ;
GANN, DS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (03) :H735-H744
[6]   CARDIOVASCULAR AND FLUID RESPONSES TO ATRIAL-NATRIURETIC-FACTOR IN SHEEP FETUS [J].
BRACE, RA ;
CHEUNG, CY .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (04) :R561-R567
[7]   THORACIC-DUCT LYMPH-FLOW AND ITS MEASUREMENT IN CHRONICALLY CATHETERIZED SHEEP FETUS [J].
BRACE, RA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (01) :H16-H20
[8]   ROLE OF CATECHOLAMINES IN MEDIATING FETAL BLOOD-VOLUME DECREASE DURING ACUTE-HYPOXIA [J].
BRACE, RA ;
CHEUNG, CY .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (04) :H927-H932
[9]   FETAL CARDIOVASCULAR, ENDOCRINE, AND FLUID RESPONSES TO ATRIAL NATRIURETIC FACTOR INFUSION [J].
BRACE, RA ;
BAYER, LA ;
CHEUNG, CY .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (03) :R580-R587
[10]   FETAL VASCULAR PRESSURE AND HEART-RATE RESPONSES TO NONLABOR UTERINE CONTRACTIONS [J].
BRACE, RA ;
BRITTINGHAM, DS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (02) :R409-R416