ASSESSMENT BY PROLONGED AMBULATORY MANOMETRY OF THE EFFECT OF ORAL CISAPRIDE ON PROXIMAL SMALL-BOWEL INTER-DIGESTIVE MOTILITY

被引:24
作者
BENSON, MJ [1 ]
CASTILLO, FD [1 ]
DEEKS, JJ [1 ]
WINGATE, DL [1 ]
机构
[1] LONDON HOSP, COLL MED, DEPT EPIDEMIOL & MED STAT, LONDON E1 2AJ, ENGLAND
关键词
GASTROINTESTINAL MOTILITY; PROKINETICS; SMALL INTESTINE; AMBULANT;
D O I
10.1007/BF01296504
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The effects of cisapride, given orally at standard therapeutic dosage (10 mg tds), on proximal small bowel interdigestive motility in ten healthy volunteers was assessed by prolonged ambulatory manometry. Cisapride did not alter the duration of the MMC cycle, duration of phase II or the propagation rate of phase III in either the daytime or nighttime periods. However, when compared to studies, in which subjects received no drug, both nighttime and daytime phase II mean contractile amplitude, but not contractile incidence, were significantly increased (P less-than-or-equal-to 0.001) by cisapride. Cisapride significantly increased the incidence of distally propagated clustered activity. We conclude that the major effects of cisapride on healthy small bowel motor function is to increase the mean contractile amplitude and incidence of distally propagated clustered activity.
引用
收藏
页码:1569 / 1575
页数:7
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