FETAL FLOOD MONONUCLEAR CELL-DIVISION IN NORMAL AND PATHOLOGICAL PREGNANCIES

被引：7

作者：

THILAGANATHAN, B ^{[1
]}

STAGIANNIS, K ^{[1
]}

MEHERHOMJI, NJ ^{[1
]}

PLACHOURAS, N ^{[1
]}

NICOLAIDES, KH ^{[1
]}

机构：

[1] KINGS COLL,SCH MED,HARRIS BIRTHRIGHT RES CTR FETAL MED,LONDON SE5 8RX,ENGLAND

来源：

FETAL DIAGNOSIS AND THERAPY | 1994年 / 9卷 / 02期

关键词：

FETAL BLOOD; CORDOCENTESIS; CELL; ANEUPLOIDY; HYPOXIA; ANEMIA;

D O I：

10.1159/000263912

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Fetal blood mononuclear cell division was measured using flow cytometry in 53 normal pregnancies and 51 pathological pregnancies complicated either by anaemia due to red blood cell isoimmunisation (RCI: n = 21), intrauterine growth retardation (SGA: n = 13) or abnormal karyotype (n = 17). In normal pregnancy, mononuclear cell division rates decreased with gestational age from a mean of 1.8% at 18 weeks to 1% at 40 weeks. Furthermore, there was a significant association between cell division and erythroblast count. The rates of cell division and erythroblast count were significantly increased in the chromosomally abnormal fetuses, and significantly decreased in the transfused RCI fetuses compared to the controls. Although the erythroblast count was elevated in the SGA fetuses, the mononuclear cell division was not significantly different from the controls. Fetal blood mononuclear cell division is elevated in early pregnancy and in chromosomally abnormal fetuses, probably as a consequence of increased numbers of circulating haemopoietic precursors. Mononuclear cell division is decreased in transfused RCI fetuses as a consequence of suppressed erythropoiesis. In SGA fetuses, despite the increased erythropoietic stimulation and erythroblastosis, cell division is not increased.

引用

页码：79 / 83

页数：5

共 18 条

[1]

Wood W.G., Developmental haemopoiesis, Blood and its Disorders, ed 2, (1982)

[2]

Brooks R., Hartwell L., Heath J., Et al., Cell growth and division, In Molecular Biology of the Cell, (1989)

[3]

Wegmann T.G., The cytokine basis for cross-talk between the maternal immune and reproductive systems, Curr Opin Immunol, 2, pp. 765-769, (1990)

[4]

Nicolaides K.H., Thilaganathan B., Mibashan R.S., Rodeck C.H., Erythroblastosis and reticulocytosis in anemic fetuses, Am J Obstet Gynecol, 159, pp. 1063-1065, (1988)

[5]

Omerod M.G., Analysis of DNA, Flow Cytometry: A Practical Approach, (1990)

[6]

Nicolaides K.H., Thilaganathan B., Mibashan R.S., Cordocentesis in the investigation of fetal erythropoiesis, Am J Obstet Gynecol, 161, pp. 1197-1220, (1989)

[7]

Wegmann T.G., Athanassakis I., Guil-Bert L., Et al., The role of M-CSF and GM-CSF in fostering placental growth, fetal growth and fetal survival, Transplant Proc, 21, pp. 566-568, (1989)

[8]

Abbas A., Thilaganathan B., Nicolaides K.H., Fetal gamma interferon concentration in normal pregnancy, Am J Obstet Gynecol, 168, pp. 1414-1416, (1993)

[9]

Thilaganathan B., Salvesen D.R., Abbas A., Et al., Fetal plasma erythropoietin concentration in red blood cell- isoimmunized pregnancies, Am J Obstet Gynecol, 167, pp. 1292-1297, (1992)

[10]

Silber R., LoBue J., Gordon A.S., Factors thought to contribute to the regulation of egress of cells from marrow

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