2 STEROIDAL EPIMERS, (5-BETA,17-ALPHA)-PREGNA-20-YNO[3,4-C][1,2,5]OXADIAZOL-17-OL (THE 5-BETA-EPIMER) AND (5-ALPHA,17-ALPHA)-PREGNA-20-YNO[3,4-C][1,2,5]OXADIAZOL-17-OL (THE 5-ALPHA-EPIMER)

被引：5

作者：

LISGARTEN, DR ^{[1
]}

PALMER, RA ^{[1
]}

MAES, D ^{[1
]}

LISGARTEN, J ^{[1
]}

WYNS, L ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS,INST MOLEK BIOL,DEPT ULTRASTRUCT,B-1640 RHODE ST GENESE,BELGIUM

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1995年 / 51卷

关键词：

D O I：

10.1107/S0108270194007237

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crystal and molecular structures of the steroidal oxadiazoles (5 beta,17 alpha)-pregna-20-yno[3,4-c][1,2,5]oxadiazol-17-ol (the 5 beta-epimer) and (5 alpha,l7 alpha)-pregna-20-yno[3,4-c][1,2,5]oxadiazol-17-ol (the 5 alpha-epimer), C21H28N2O2, have been determined. In both structures rings A are similar, having conformations intermediate between a strained sofa, a half-chair and an envelope. Rings B and C are also similar, adopting chair conformations. In the 5 beta-epimer, ring D has a 13 beta-envelope conformation, while in the 5 alpha-epimer, ring D has an envelope/intermediate half-chair conformation.

引用

页码：666 / 670

页数：5

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