GROWING BONES ON COMPUTER - SOME PITFALLS OF A COMPUTER SIMULATION OF EFFECTS OF RADIATION ON BONE GROWTH

被引：16

作者：

KEMBER, NF

机构：

[1] Department of Medical Physics, Royal Free Hospital School of Medicine, London, WCl

来源：

CELL AND TISSUE KINETICS | 1969年 / 2卷 / 01期

关键词：

D O I：

10.1111/j.1365-2184.1969.tb00333.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The linear arrangement of the proliferating cells in the growth cartilage of bone provides an apparently simple system for studying the relationship of cell kinetics to a gross endpoint, i.e. bone growth. The system has been reduced to a simple computer model which follows the effects of radiation on the growth of fifty or one hundred individual cartilage columns. When the computed data were compared with experimental curves some factors were discovered that had been omitted from the original model. A revised model proved of limited value in sorting out the relative importance of competing kinetic parameters but indicated some directions for future experimental studies. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：11 / &

共 15 条

[1]

BARRETT JC, 1966, J NATL CANCER I, V37, P443

[2] CELL PROLIFERATION STUDIES IN INTESTINAL EPITHELIUM OF RAT .2. THEORETICAL ASPECTS [J].