SYNTHESIS OF EMETINE AND RELATED COMPOUNDS .8. SYNTHESIS OF TUBULOSINE AND ISOTUBULOSINE

被引：19

作者：

OPENSHAW, HT

WHITTAKE.N

机构：

[1] Wellcome Research Laboratories, Beckenham, Kent

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 01期

关键词：

D O I：

10.1039/j39690000091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The constitution (Ic) assigned to tubulosine {3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-(1,2,3,4-tetrahydro-6-hydroxy- β-carbolin-1-yl)-2H-benzo[a]quinolizine} has been confirmed by total synthesis from the (-)-ester (II) (ethyl 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizine-2-acetate) of known configuration. Isotubulosine (Vc), also produced in the synthesis, has been identified with an alkaloid subsequently isolated from Alangium lamarckii.

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页码：91 / +

页数：1

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