NEW METHOD OF PREPARATION OF PYOCYANIN AND DEMONSTRATION OF AN UNUSUAL BACTERIAL SENSITIVITY

被引:60
作者
KNIGHT, M
HARTMAN, PE
HARTMAN, Z
YOUNG, VM
机构
[1] JOHNS HOPKINS UNIV,DEPT CORP RES & DEV,BALTIMORE,MD 21218
[2] UNIV MARYLAND HOSP,NCI,BALTIMORE CANC RES CTR,DIV CANC TREATMENT,BALTIMORE,MD 21201
关键词
D O I
10.1016/0003-2697(79)90179-9
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Pyocyanin was prepared in 60% yield from phenazine methoxysulfate by a photooxidation procedure and purification by silica gel chromatography. Monitoring was performed by thin-layer chromatography. Approximately 50% of clinical Pseudomonas aeruginosa isolates were found to produce pyocyanin at 37°C. Among Proteus strains, P. morganii strains were sensitive to concentrations of pyocyanin 16 to 64 times lower than concentrations that inhibited the growth of P. mirabilis and P. vulgaris strains. © 1979.
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页码:19 / 23
页数:5
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