IMMUNOLOGICAL CROSS-REACTIVITY BETWEEN ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN AND CHOLERA TOXIN-A AND TOXIN-B SUBUNITS

被引：31

作者：

HOLMGREN, J

SVENNERHOLM, AM

机构：

[1] Institute of Medical Microbiology, University of Göteborg, Göteborg, S-413 46

来源：

CURRENT MICROBIOLOGY | 1979年 / 2卷 / 01期

关键词：

D O I：

10.1007/BF02601736

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It was shown by immunoenzyme methods and neutralization tests that Escherichia coli heat-labile entorotoxin cross-reacts immunologically with both the A and B subunits of cholera toxin. In addition to the shared structures, both toxins had unique antigenic determinants. The toxin-neutralizing capacity of anti-B antibody was considerably higher than that of anti-A antibody, as tested in the adrenal cell and rabbit skin assays. In intestinal loops, however, the neutralizing potencies of anti-A and anti-B were similar, possibly reflecting that in this system mere cross-linking of toxin by antibody inhibits its diffusion through mucus. © 1979, Springer-Verlag New York Inc. All rights reserved.

引用

页码：55 / 58

页数：4

共 28 条

[1] MECHANISM OF CHOLERA TOXIN ACTION - COVALENT MODIFICATION OF GUANYL NUCLEOTIDE-BINDING PROTEIN OF ADENYLATE-CYCLASE SYSTEM [J].