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POTENTIATION OF CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY BY 1,3-BUTANEDIOL

被引：26
作者：
HEWITT, WR
PLAA, GL
机构：
[1] Département de pharmacologie Faculté, médecine Université de Montréal, Montréal
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 1979年 / 47卷 / 01期
关键词：
D O I：
10.1016/0041-008X(79)90084-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The hepatotoxic respone to a small acute challenge dose of carbon tetrachloride was evaluated in rats following production of metabolic ketosis by 1,3-butanediol (BD) administration. Neither BD alone or CCl4 alone produced an appreciable degree of hepatotoxicity. In contrast, CCl4 administration produced marked hepatotoxicity in rats rendered ketotic by BD. © 1979.
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页码：177 / 180
页数：4
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