SEROTONIN AND DOPAMINE METABOLITES IN BRAIN-REGIONS AND CEREBROSPINAL-FLUID OF A PRIMATE SPECIES - EFFECTS OF KETAMINE AND FLUPHENAZINE

被引：76

作者：

BACOPOULOS, NG ^{[1
]}

REDMOND, DE ^{[1
]}

ROTH, RH ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 04期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb11048.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The concentration of dopamine (DA) and serotonin (5‐HT) metabolites in brain regions was not altered by doses of ketamine (10mg/kg) which induced dissociative anesthesia in a primate species. Cercopithecus aethiops. Fluphenazine (1.0mg/kg) increased homovanillic acid (HVA) content in all brain regions examined. An increase in HVA and 5‐hydroxyindoleacetic acid (5‐HIAA) concentration was observed in cisternal CSF 4 h after ketamine without a concomitant change in the brain concentration of these metabolites. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：1215 / 1218

页数：4

共 23 条

[1] EFFECTS OF HALOPERIDOL AND PROBENECID ON PLASMA AND CSF DOPAMINE METABOLITES IN RHESUS-MONKEY (MACACCA-MULATTA) [J].