LIVER MICROSOMAL OXIDATIONS IN BABOON (PAPIO-PAPIO)

被引：2

作者：

GEE, SJ

KRIEGER, RI

机构：

[1] Department of Environmental Toxicology, University of California, Davis, CA

来源：

XENOBIOTICA | 1979年 / 9卷 / 08期

关键词：

D O I：

10.3109/00498257909087259

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The activity of baboon (Papio papio) hepatic microsomes was evaluated using several model substrates. 2. As with other species studied in this laboratory, baboon microsomal enzyme activities were in the decreasing order: aldrin epoxidation > p-nitroanisole O-demethyl-ation > dihydroisodrin hydroxylation > benzo(a)pyrene oxidations. 3. Substrate, time, protein and cofactor requirements were examined. 4. Activities of stored frozen tissue and microsomal pellets remained similar up to seven days. 5. In the six animals studied (three male, three female), no differences in hepatic microsomal activity due to sex were apparent. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：459 / 465

页数：7

共 30 条

[1]

ALLEY MC, 1977, THESIS U CALIFORNIA

[2] MICROSOMAL DRUG-METABOLIZING-ENZYMES IN OLIVE BABOON (PAPIO-ANABIS) [J].