USE OF DIMETHYLDIOXIRANE IN THE PREPARATION OF EPOXY DERIVATIVES RELATED TO INSECT JUVENILE HORMONES

被引：33

作者：

MESSEGUER, A

SANCHEZBAEZA, F

CASAS, J

HAMMOCK, BD

机构：

[1] UNIV CALIF DAVIS,DEPT ENTOMOL,DAVIS,CA 95616

[2] UNIV CALIF DAVIS,DEPT ENVIRONM TOXICOL,DAVIS,CA 95616

来源：

TETRAHEDRON | 1991年 / 47卷 / 07期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4020(01)86386-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A study on the epoxidation of methyl farnesoate using the title reagent has been carried out. In addition, dimethyldioxirane has shown to be a convenient reagent for the synthesis of putative metabolites of juvenile hormone III, such as diepoxide 4, triepoxide 5 and epoxy diol 7. This reagent has also shown to be an excellent tool for performing the preparation of tritium labelled derivatives 4 and 7. Finally, molecular mechanics and NMR studies for the characterisation of cis and trans tetrahydrofuran derivatives 8a and 8b, compounds resulting from the acid or enzymatic hydrolysis of epoxy diol 7, are also reported.

引用

页码：1291 / 1302

页数：12

共 19 条

[1]

AAM W, 1989, ACCOUNTS CHEM RES, V22, P205

[2] DIMETHYLDIOXIRANE EPOXIDATION OF ALPHA,BETA-UNSATURATED KETONES, ACIDS AND ESTERS [J].