SPECIFIC SULFONATION OF TYROSINE, TRYPTOPHAN AND HYDROXY-AMINO ACIDS IN PEPTIDES

被引：17

作者：

PREVIERO, A ^{[1
]}

CAVADORE, JC ^{[1
]}

TORREILLES, J ^{[1
]}

COLETTIPREVIERO, MA ^{[1
]}

机构：

[1] INSERM,UNITE RECH 58,F-34100 MONTPELLIER,FRANCE

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 581卷 / 02期

关键词：

Enkephalin; Peptide modification; Serine O-sulfate; Threonine O-sulfate; Tryptophan disulfonic acid; Tyrosine 3-sulfonic acid;

D O I：

10.1016/0005-2795(79)90247-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. ClSO3H in trifluoroacetic acid rapidly converts serine and threonine into O-sulfate ester derivatives while tyrosine and tryptophan are converted into arylsufonic acids. 2. 2. H2SO4 in trifluoroacetic acid reacts more slowly with serine, threonine and tyrosine while is not able to modify tryptophan. 3. 3. All other amino acids are perfectly stable under the above reaction conditions. 4. 4. Peptides containing susceptible amino acid residues are specifically converted into the corresponding sulfonated derivatives in high or quantitative yield. © 1979.

引用

页码：276 / 282

页数：7

共 9 条

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BHACCA NS, 1962, NMR SPECTRA CATALOG

[2] ON THE [S-35] SULPHATE INCORPORATION IN FIBRINOPEPTIDE-B FROM RABBIT FIBRINOGEN [J].