EVALUATION OF A SYSTEM FOR THE DELIVERY OF INHALED BECLOMETHASONE DIPROPIONATE TO INTUBATED NEONATES

被引:21
作者
ROZYCKI, HJ [1 ]
BYRON, PR [1 ]
DAILEY, K [1 ]
GUTCHER, GR [1 ]
机构
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARM,RICHMOND,VA 23298
来源
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS | 1991年 / 16卷 / 02期
关键词
BRONCHOPULMONARY DYSPLASIA; DRUG DELIVERY; BECLOMETHASONE DIPROPIONATE; AERODYNAMIC PARTICLES;
D O I
10.1159/000480560
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Since systemic dexamethasone therapy for bronchopulmonary dysplasia is associated with numerous side effects, a simple system to deliver aerosolized beclomethasone dipropionate (BDP) directly to the lungs of intubated neonates was developed and evaluated in vitro. The system consists of a self-inflating bag, metered dose inhaler (MDI) adapter, Tygon spacer and endotracheal tube (ETT). A dose is delivered by discharging the MDI into the system and giving 3 'breaths' with the bag. Different sizes of ETT do not affect the drug output (1.17 +/- 0.29 vs. 1.32 +/- 0.34-mu-g of BDP per dose using a 3.0-mm or 3.5-mm ETT, respectively; means +/- SD). However, a shorter system spacer substantially reduces the drug output. The majority (54.0%) of the particles exiting the ETT and available to the patient are in the respirable range (0.5-5.5-mu-m). Based on adult doses and delivery of BDP and the relative sizes of the adult and neonatal lung, it is estimated that a neonate will require 1-6 doses/day. Replacing dexamethasone in the treatment of bronchopulmonary dysplasia with aerosol topical steroids delivered by this system may improve both the safety and efficacy.
引用
收藏
页码:65 / 70
页数:6
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