QUANTITATIVE-DETERMINATION OF NEW BETA-BLOCKER, ATENOLOL, IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：21

作者：

DECOURT, S ^{[1
]}

FLOUVAT, B ^{[1
]}

机构：

[1] HOP AMBROISE PARE, DEPT PHARMACOL, TOXICOL LAB, F-92100 BOULOGNE, FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 174卷 / 01期

关键词：

D O I：

10.1016/S0021-9673(00)87065-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

High performance liquid phase chromatography was used to study atenolol. The plasma and urine of subjects not given atenolol (controls) were treated with 0.5 .mu.g atenolol for use in integration. Plasma and urine of treated subjects were studied. The chromatogram of a subject given two 1000 mg atenolol tablets 4 h after oral administration is presented. Extraction methods are described. Adsorption chromatography on a silica column and a UV detector gave sensitive and reproducible results. The plasma of subjects with normal or insufficient renal function was also studied by a spectrofluorimetric technique. Atenolol is used in the treatment of arterial hypertension.

引用

页码：258 / 263

页数：6

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