ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS EFFECTS OF CATIONIC METALLOPORPHYRIN ELLIPTICINE COMPLEXES

被引：50

作者：

LI, D

BALZARINI, J

SCHOLS, D

MEUNIER, B

DECLERCO, E

机构：

[1] CNRS, CHIM COORDINAT LAB, 205 ROUTE NARBONNE, F-31077 TOULOUSE, FRANCE

[2] CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 08期

关键词：

D O I：

10.1016/0006-2952(92)90486-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of cationic metalloporphyrin-ellipticine complexes were found to inhibit the cytopathicity of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus in MT-4 cells at concentrations ranging from 1.4 to 17 mug/mL, i.e. at a concentration that was 2.5-30-fold below the cytotoxicity threshold. These compounds were also found to inhibit syncytium formation between persistently HIV-1-infected HUT-78 and uninfected Molt/4 cells, to interfere with HIV-1 binding to the cells, and to suppress HIV-1-associated reverse transcriptase activity.

引用

收藏

页码：1675 / 1679

页数：5

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