SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

被引：20

作者：

ANDERSEN, A

CORNETT, C

LAURIDSEN, A

OLSEN, CE

CHRISTENSEN, SB

机构：

[1] ROYAL DANISH SCH PHARM,PHARMABIOTEC,DEPT ORGAN CHEM,UNIV PARKEN 2,DK-2100 COPENHAGEN,DENMARK

[2] ROYAL VET & AGR UNIV,DEPT CHEM,DK-1871 FREDERIKSBERG,DENMARK

[3] ROYAL DANISH SCH PHARM,PHARMABIOTEC,DEPT GEN CHEM,DK-2100 COPENHAGEN,DENMARK

来源：

ACTA CHEMICA SCANDINAVICA | 1994年 / 48卷 / 04期

关键词：

D O I：

10.3891/acta.chem.scand.48-0340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.

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页码：340 / 346

页数：7

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