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AUTOMATED-ANALYSIS OF NUCLEAR-MAGNETIC-RESONANCE ASSIGNMENTS FOR PROTEINS

被引：45
作者：
ZIMMERMAN, DE
MONTELIONE, GT
机构：
[1] Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854-5638
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 05期
关键词：
D O I：
10.1016/0959-440X(95)80060-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent developments in protein NMR technology provide spectral data that are highly amenable to analysis by computer software systems. Automated methods of analysis use constraint satisfaction, pseudoenergy minimization, directed search, neural net, simulated annealing, and/or genetic algorithms to establish sequential links and sequence-specific assignments. The most advanced systems provide automated analysis of complete backbone and extensive side-chain resonance assignments for proteins of 50-150 amino acids.
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收藏
页码：664 / 673
页数：10
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