INHIBITION OF CHEMOTACTIC MIGRATION OF HUMAN NEUTROPHILIC GRANULOCYTES BY RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR

被引：24

作者：

KOWNATZKI, E ^{[1
]}

LIEHL, E ^{[1
]}

ASCHAUER, H ^{[1
]}

UHRICH, S ^{[1
]}

机构：

[1] SANDOZ GMBH, A-1235 VIENNA, AUSTRIA

来源：

IMMUNOPHARMACOLOGY | 1990年 / 19卷 / 02期

关键词：

Chemotaxis; Cytokine; GM-CSF; Neutrophilic granulocyte;

D O I：

10.1016/0162-3109(90)90049-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was analysed for effects on the migration of human neutrophilic granulocyte by the Boyden chamber assay. At concentrations ranging from 0.1 to 10 000 U/ml (or 10-12 to 10-7 mol/1) GM-CSF had neither chemokinetic nor chemotactic activity. When added to the cells in the upper compartment of the chamber GM-CSF dose-dependently inhibited the chemotactic migration towards the tripeptide f-Met-Leu-Phe and the complement split product C5a. Chemotaxis towards f-Met-Leu-Phe was inhibited more efficiently by GM-CSF than C5a-induced migration. © 1990.

引用

页码：139 / 143

页数：5

共 23 条

[1] HUMAN RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR INCREASES CELL-TO-CELL ADHESION AND SURFACE EXPRESSION OF ADHESION-PROMOTING SURFACE GLYCOPROTEINS ON MATURE GRANULOCYTES
ARNAOUT, MA
WANG, EA
CLARK, SC
SIEFF, CA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (02) : 597 - 601
[2] ATKINSON YH, 1988, IMMUNOLOGY, V64, P519
[3] CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES
BOYDEN, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1962, 115 (03) : 453 - &
[4] ENGLISH D, 1988, J IMMUNOL, V141, P2400
[5] FLETCHER MP, 1988, BLOOD, V71, P652
[6] PURIFIED HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR - DIRECT ACTION ON NEUTROPHILS
GASSON, JC
WEISBART, RH
KAUFMAN, SE
CLARK, SC
HEWICK, RM
WONG, GG
GOLDE, DW
[J]. SCIENCE, 1984, 226 (4680) : 1339 - 1342
[7] GRIFFIN JD, 1984, BLOOD, V63, P904
[8] HUMAN GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR - AN EFFECTIVE DIRECT ACTIVATOR OF HUMAN POLYMORPHONUCLEAR NEUTROPHILIC GRANULOCYTES
KAPP, A
ZECKKAPP, G
DANNER, M
LUGER, TA
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1988, 91 (01) : 49 - 55
[9] THE OLIGOPEPTIDE CHEMOTACTIC FACTOR RECEPTOR ON HUMAN POLYMORPHONUCLEAR LEUKOCYTE MEMBRANES EXISTS IN 2 AFFINITY STATES
KOO, C
LEFKOWITZ, RJ
SNYDERMAN, R
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 106 (02) : 442 - 449
[10] GUANINE-NUCLEOTIDES MODULATE THE BINDING-AFFINITY OF THE OLIGOPEPTIDE CHEMOATTRACTANT RECEPTOR ON HUMAN POLYMORPHONUCLEAR LEUKOCYTES
KOO, C
LEFKOWITZ, RJ
SNYDERMAN, R
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (03) : 748 - 753

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