REDUCTION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ANTIGENS ON INVASIVE AND HIGH-GRADE TRANSITIONAL CELL-CARCINOMA

被引：30

作者：

TOMITA, Y ^{[1
]}

MATSUMOTO, Y ^{[1
]}

NISHIYAMA, T ^{[1
]}

FUJIWARA, M ^{[1
]}

机构：

[1] NIIGATA UNIV,SCH MED,DEPT UROL,NIIGATA 951,JAPAN

来源：

JOURNAL OF PATHOLOGY | 1990年 / 162卷 / 02期

关键词：

Major histocompatibility complex antigens; transitional cell carcinoma; β‐2; microglobulin; immunohistochemistry;

D O I：

10.1002/path.1711620209

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined immunohistologically the expression of major histocompatibility complex (MHC) class I and II antigens, which play important roles in immune reactions, on transitional cell carcinoma (TCC). When stained with monoclonal antibody W6/32 against class I antigens, reduced staining was observed in 34 of 46 TCCs and was virtually absent in 15 of these. The cases showing reduced staining were much more frequent (29 of 34) in high‐ to moderategrade than in low‐grade TCC. Furthermore, class I antigens were reduced in 18 of 19 invasive TCCs, but in 16 of 27 superficial TCCs. Thus, the reduction of class I antigens was correlated significantly with a decreased degree of tumour cell differentiation and the presence of invasion. Class II antigens on TCC showed variable expression and were not related to tumour grade or stage. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：157 / 164

页数：8

共 42 条

[1] REACTIVITY OF HUMAN LYMPHOID AND LYMPHOBLASTOID-CELLS WITH PEANUT AGGLUTININ - DETECTION OF A BLOOD-CELL SUBSET WHICH LACKS DETECTABLE MEMBRANE HLA [J].