INTRODUCTION OF A METHOXYL GROUP INTO INDOLES AND 2,3-DIHYDROINDOLES - NEW SYNTHESIS OF 5-HYDROXYTRYPTAMINE (SEROTONIN)

被引：31

作者：

SAITO, K

KIKUGAWA, Y

机构：

[1] Faculty of Pharmaceutical Sciences, Josai University, Saitama, 350-02, 1-1 Keyakidai, Sakado-shi

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1979年 / 16卷 / 07期

关键词：

D O I：

10.1002/jhet.5570160707

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methoxylation of the 5‐position of indoles and indolines was investigated. Treatment of 5‐bromo‐iodoles and indolines with cuprous iodide and sodium methoxide in methanol/dimethylformamide afforded the corresponding methoxy compounds. This methoxylation reaction was applied to the new synthesis of serotonin. Copyright © 1979 Journal of Heterocyclic Chemistry

引用

页码：1325 / 1328

页数：4

共 24 条

[1]

AKERMARK B, 1975, J ORG CHEM, V40, P1365, DOI 10.1021/jo00897a048

[2]

ASERO B, 1952, LIEBIGS ANN CHEM, V576, P69

[3] SYNTHESIS OF THE 3-2'-AMINOPROPYL-DERIVATIVES AND 3-2'-AMINOBUTYL-DERIVATIVES OF 5-HYDROXYINDOLE, AND AN ALTERNATIVE SYNTHESIS OF 5-HYDROXYTRYPTAMINE [J].