ISOLATION OF 2 TOXIC HEPTAPEPTIDE MICROCYSTINS FROM AN AXENIC STRAIN OF MICROCYSTIS-AERUGINOSA, K-139

被引：81

作者：

HARADA, K

OGAWA, K

MATSUURA, K

NAGAI, H

MURATA, H

SUZUKI, M

ITEZONO, Y

NAKAYAMA, N

SHIRAI, M

NAKANO, M

机构：

[1] NIPPON ROCHE RES CTR,KAMAKURA,KANAGAWA 247,JAPAN

[2] IBARAKI UNIV,DEPT AGR CHEM,AMI,IBARAKI 30003,JAPAN

[3] JICHI MED SCH,DEPT MICROBIOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

来源：

TOXICON | 1991年 / 29卷 / 4-5期

关键词：

D O I：

10.1016/0041-0101(91)90022-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two toxic heptapeptides were isolated from an axenic Microcystis aeruginosa strain, K-139. Using mainly a non-destructive NMR method, we determined the structure of the major toxin to be 7-desmethylmicrocystin LR which lacks an N-methyl group of the dehydroalanine moiety of microcystin LR. The minor toxin was deduced to be 3,7-didesmethylmicrocystin LR. The chromatographic and NMR analyses of 7-desmethylmicrocystin LR were compared with those of 3-desmethylmicrocystin LR.

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页码：479 / 489

页数：11

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