EFFECT OF EPINEPHRINE ON END-TIDAL CARBON-DIOXIDE MONITORING DURING CPR

被引：50

作者：

MARTIN, GB

GENTILE, NT

PARADIS, NA

MOEGGENBERG, J

APPLETON, TJ

NOWAK, RM

机构：

[1] Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI

来源：

ANNALS OF EMERGENCY MEDICINE | 1990年 / 19卷 / 04期

关键词：

coronary perfusion pressure; CPR; end-tidal carbon dioxide;

D O I：

10.1016/S0196-0644(05)82345-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

End-tidal carbon dioxide (ETco2) has been shown to correlate with coronary perfusion pressure (CPP) during CPR and has been proposed as a useful noninvasive monitor of CPR efficacy. The effects of therapeutic epinephrine dosing on ETco2 and CPP in six dogs were examined. Ventricular fibrillation was induced and left untreated for five minutes before CPR was initiated. After five minutes of CPR, epinephrine 0.045 mg/kg IV was administered. CPP and ETco2 were compared immediately before and two minutes after epinephrine administration. There was a significant increase in CPP from 12.2 ± 9.6 to 26.8 ± 7.1 mm Hg (P = .006) after epinephrine. This was accompanied by a significant decrease in ETco2 from 8.2 ± 2.9 to 3.8 ± 2.0 mm Hg (P = .01). These data indicate that after epinephrine administration, caution must be exercised in using ETco2 as an indicator of CPP. © 1990 American College of Emergency Physicians.

引用

页码：396 / 398

页数：3

共 11 条

[1]

Sanders, Ewy, Bragg, Et al., Expired PCO2 as a prognostic indicator of successful resuscitation from cardiac arrest, Ann Emerg Med, 14, pp. 948-952, (1985)

[2]

Gudipati, Weil, Bisera, Et al., Expired carbon dioxide: A noninvasive monitor of cardiopulmonary resuscitation, Circulation, 77, pp. 234-239, (1988)

[3]

Trevino, Bisera, Weil, Et al., End-tidal CO2 as a guide to successful cardiopulmonary resuscitation: A preliminary report, Crit Care Med, 13, pp. 910-911, (1985)

[4]

Kern, Sanders, Voorhees, Et al., Dynamic changes in expired end-tidal carbon dioxide as a prognostic guide during CPR in dogs, Ann Emerg Med, 17, pp. 392-393, (1988)

[5]

Barton, Callaham, Successful prediction by capnometry of resuscitation from cardiac arrest, Annals of Emergency Medicine, 17, (1988)

[6]

Sanders, Kern, Otto, Et al., End-tidal carbon dioxide monitoring during cardiopulmonary resuscitation: A prognostic indicator for survival, JAMA, 262, pp. 1347-1351, (1989)

[7]

Gazmuri, von Planta, Weil, Et al., Arterial PCO2 as an indicator of systemic perfusion during cardiopulmonary resuscitation, Crit Care Med, 17, pp. 237-240, (1989)

[8]

Appleton, Paradis, Martin, Et al., Coronary perfusion pressures during CPR are higher in patients with eventual return of spontaneous circulation, Annals of Emergency Medicine, 18, (1989)

[9]

Brown, Werman, Davis, Et al., The effect of high-dose phenylephrine versus epinephrine on cerebral blood flow during CPR, Ann Emerg Med, 16, pp. 743-748, (1987)

[10]

Brown, Werman, Davis, Et al., The effect of graded doses of epinephrine on regional myocardial blood flow during cardiopulmonary resuscitation in swine, Circulation, 75, pp. 491-497, (1987)

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