ANTIMICROBIAL ACTIVITY AND SPECTRUM OF CEFTIBUTEN (7432-S, SCH-39720) - A REVIEW OF UNITED-STATES AND CANADIAN RESULTS

Preliminary in vitro studies of ceftibuten in the United States and Canada have demonstrated a potent activity against enteric bacilli ( > 90% of routine clinical isolates), Haemophilus influenzae, Moraxella catarrhalis, Neisseria spp., most B-hemolytic streptococci, and Streptococcus pneumoniae. Ceftibuten was demonstrated to be bactericidal, minimally influenced by high inocula, beta-lactamase stable, an inhibitor of type Ia-beta-lactamase, and potentially usable against some Entero-bacteriaceae strains capable of destroying other newer cephalosporins (ceftazidime and cefixime). In vitro test methods have been standardized, and preliminary quality control guidelines have been proposed for clinical trials. The ceftibuten spectrum seems best suited for therapy of urinary tract, respiratory, and genital tract infections as an alternative to older oral cephalosporins, recently marketed esters (cefuroxime axetil), and cefixime.