THE IGA AND SUBCLASS IGG RESPONSES AND PROTECTION IN MICE IMMUNIZED WITH INFLUENZA ANTIGENS ADMINISTERED AS ISCOMS, WITH FCA, ALH OR AS INFECTIOUS VIRUS

被引：4

作者：

AHMEIDA, ETSB ^{[1
]}

JENNINGS, R ^{[1
]}

ERTURK, M ^{[1
]}

POTTER, CW ^{[1
]}

机构：

[1] UNIV SHEFFIELD, SCH MED, DEPT EXPTL & CLIN MICROBIOL, BEECH HILL RD, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND

来源：

ARCHIVES OF VIROLOGY | 1992年 / 125卷 / 1-4期

关键词：

D O I：

10.1007/BF01309629

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Comparative studies on the local IgA, and circulating IgG subclass antibody responses of mice to A/Sichuan/2/87 (H3N2) influenza virus surface antigens administered with different carrier or delivery systems by the parenteral route, were carried out. The results obtained were compared with the responses observed following live influenza virus infection, and the protection afforded to these animals by these various preparations determined. Infection with live virus elicited early and high levels of protection against homologous virus challenge and this correlated with both local IgA and circulating IgG2a antibody levels. When incorporated into immunostimulating complexes (ISCOMS), A/Sichuan surface antigens promoted high levels of local IgA and circulating IgG1 antibody, and achieved a more rapid and more solid immunity against homologous virus challenge infection, than that elicited by the same surface antigens administered alone or together with Freund's complete adjuvant or alhydrogel.

引用

页码：71 / 86

页数：16

共 32 条

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