ENZYMICHROMISM - DETERMINATION OF THE DIELECTRIC-PROPERTIES OF AN ENZYME ACTIVE-SITE

被引：35

作者：

KANSKI, R ^{[1
]}

MURRAY, CJ ^{[1
]}

机构：

[1] UNIV ARKANSAS,DEPT CHEM & BIOCHEM,FAYETTEVILLE,AR 72701

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)77589-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The negative solvatochromic and enzymichromic properties of 4-carbamidopyridinium cyclopentadienylide, 3, are presented. Tle 78 nm bathochromic shift of the long wavelength absorption band of 3 upon going from water to the horse liver alcohol dehydrogenase (HLADH)-NADH ternary complex is consistent with a low dielectric for the hydrophobic binding pocket of this enzyme.

引用

页码：2263 / 2266

页数：4

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