REPRODUCTIVE TOXICITY AND TOXICOKINETICS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN .3. EFFECTS OF SINGLE DOSES ON THE TESTIS OF MALE-RATS

被引：22

作者：

CHAHOUD, I ^{[1
]}

HARTMANN, J ^{[1
]}

RUNE, GM ^{[1
]}

NEUBERT, D ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST ANAT,W-1000 BERLIN 33,GERMANY

来源：

ARCHIVES OF TOXICOLOGY | 1992年 / 66卷 / 08期

关键词：

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD); TESTIS; NUMBER OF SPERMATIDS; NOAEL;

D O I：

10.1007/BF01973387

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The effects of a single dose of TCDD on the testis were studied in rats. The animals were treated (subcutaneously) once with TCDD doses of 0, 0.5, 1.0, 3.0, 5.0 mug/kg body weight. Doses of 3.0 or 5.0 mug TCDD/kg reduced the number of spermatids/testis significantly (60% of the controls). Electron microscopic inspection revealed that both doses led to a dissolution on the germinal epithelium. Altered germ cells at all developmental stages occurred in all testes evaluated. Doses of 0.5 or 1.0 mug TCDD/kg did not induce any effects in the testis; therefore, under these experimental conditions of single exposure to rats the dose of 1.0 mug TCDD/kg can be considered as NOAEL.

引用

页码：567 / 572

页数：6

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