ISRADIPINE IS ABLE TO SEPARATE MORPHINE-INDUCED ANALGESIA AND PLACE CONDITIONING

被引：22

作者：

KUZMIN, A ^{[1
]}

PATKINA, N ^{[1
]}

PCHELINTSEV, M ^{[1
]}

ZVARTAU, E ^{[1
]}

机构：

[1] IP PAVLOV MED INST,DEPT PHARMACOL,PHARMACOL NARCOT LAB,LEV TOLSTOY STR 68,ST PETERSBURG 197089,USSR

来源：

BRAIN RESEARCH | 1992年 / 593卷 / 02期

关键词：

MORPHINE; ISRADIPINE; ANALGESIA; REINFORCING PROPERTY; PLACE CONDITIONING;

D O I：

10.1016/0006-8993(92)91311-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an aquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strengthen morphine-induced analgesia as measured by tail-clip and hot-plate tests in mice and tail-clip and tail-flick tests in rats. The results suggest that analgesic and reinforcing effects of morphine might be pharmacologically separated by isradipine.

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页码：221 / 225

页数：5

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