SYNTHESIS AND ANTITUMOR-ACTIVITY OF SOME NEW 2-CHLOROETHYLNITROSOUREAS

被引：14

作者：

FILIPPATOS, E ^{[1
]}

PAPADAKIVALIRAKI, A ^{[1
]}

ROUSSAKIS, C ^{[1
]}

VERBIST, JF ^{[1
]}

机构：

[1] FAC PHARM NANTES,F-44035 NANTES 01,FRANCE

来源：

ARCHIV DER PHARMAZIE | 1993年 / 326卷 / 08期

关键词：

D O I：

10.1002/ardp.19933260805

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of N-(2-chloroethyl)-N'-(9H-xanthen-9-yl)-N-nitrosoureas and N-(2-chloroethyl)-N'-(9H-thioxanthen-9-yl)-N-nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N-(2-chloroethyl)-N'-(2-methoxy-9H-xanthen-9-yl)-N-nitrosourea (8e) was active against leukemia P388 tumor system in mice.

引用

页码：451 / 456

页数：6

共 22 条

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