POLYGENIC EXPRESSION OF SOMATOSTATIN IN LAMPREY

被引：32

作者：

SOWER, SA ^{[1
]}

CHIANG, YC ^{[1
]}

CONLON, JM ^{[1
]}

机构：

[1] CREIGHTON UNIV,SCH MED,DEPT BIOMED SCI,CTR REGULATORY PEPTIDE,OMAHA,NE 68178

来源：

PEPTIDES | 1994年 / 15卷 / 01期

基金：

美国国家科学基金会;

关键词：

SOMATOSTATIN; AGNATHAN; LAMPREY BRAIN; POSTTRANSLATIONAL PROCESSING;

D O I：

10.1016/0196-9781(94)90184-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have led to the identification of three biosynthetically related molecular forms of somatostatin (somatostatin-14, -34 and -37) from the pancreas of the sea lamprey (Petromyzon marinus). We have now isolated from the brain of the same species a second form of somatostatin-14 that is identical to mammalian somatostatin-14 and differs from lamprey pancreatic somatostatin-14 by the substitution Ser(12) to Thr. Larger forms of somatostatin were not identified in lamprey brain in this study. These data suggest that the two molecular forms of lamprey somatostatin-14 are the products of different genes that are expressed in a tissue-specific manner.

引用

页码：151 / 154

页数：4

共 15 条

[1]

ANDREWS PC, 1988, J BIOL CHEM, V263, P15809

[2] HYPOTHALAMIC POLYPEPTIDE THAT INHIBITS SECRETION OF IMMUNOREACTIVE PITUITARY GROWTH-HORMONE [J].

BRAZEAU, P ;

VALE, W ;

BURGUS, R ;

LING, N ;

BUTCHER, M ;

RIVIER, J ;

GUILLEMIN, R .

SCIENCE, 1973, 179 (4068) :77-79

[3] [SER5]-SOMATOSTATIN-14 - ISOLATION FROM THE PANCREAS OF A HOLOCEPHALAN FISH, THE PACIFIC RATFISH (HYDROLAGUS-COLLIEI) [J].

CONLON, JM .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1990, 80 (02) :314-320

[4] PRIMARY STRUCTURES OF SOMATOSTATINS FROM THE ISLET ORGAN OF THE HAGFISH SUGGEST AN ANOMALOUS PATHWAY OF POSTTRANSLATIONAL PROCESSING OF PROSOMATOSTATIN-1 [J].

CONLON, JM ;

ASKENSTEN, U ;

FALKMER, S ;

THIM, L .

ENDOCRINOLOGY, 1988, 122 (05) :1855-1859

[5] SOMATOSTATIN-RELATED AND GLUCAGON-RELATED PEPTIDES WITH UNUSUAL STRUCTURAL FEATURES FROM THE EUROPEAN EEL (ANGUILLA-ANGUILLA) [J].

CONLON, JM ;

DEACON, CF ;

HAZON, N ;

HENDERSON, IW ;

THIM, L .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1988, 72 (02) :181-189

[6]

CONLON JM, 1990, PROG CLIN BIOL RES, V342, P10

[7] RELATIONSHIP BETWEEN BRAIN GONADOTROPIN-RELEASING-HORMONE AND FINAL REPRODUCTIVE PERIOD OF THE ADULT MALE SEA LAMPREY, PETROMYZON-MARINUS [J].

FAHIEN, CM ;

SOWER, SA .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1990, 80 (03) :427-437

[8] CLONING AND SEQUENCE-ANALYSIS OF CDNAS ENCODING 2 DISTINCT SOMATOSTATIN PRECURSORS FOUND IN THE ENDOCRINE PANCREAS OF ANGLERFISH [J].

HOBART, P ;

CRAWFORD, R ;

SHEN, LP ;

PICTET, R ;

RUTTER, WJ .

NATURE, 1980, 288 (5787) :137-141

[9]

NOZAKI M, 1984, BIOMED RES S, V36, P135

[10] SOMATOSTATIN IN HYPOTHALAMUS, EXTRAHYPOTHALAMIC BRAIN, AND PERIPHERAL TISSUES OF RAT [J].

PATEL, YC ;

REICHLIN, S .

ENDOCRINOLOGY, 1978, 102 (02) :523-530

← 1 2 →